Does Mounjaro cause depression or anxiety?

Mounjaro (tirzepatide) is a medication approved to treat type 2 diabetes and support weight loss. While most people tolerate it well, there have been some reports of mood-related changes, such as depression or anxiety, though these are not listed as common side effects in clinical trials.

Here’s what current evidence says:

• Clinical trials for Mounjaro have not shown a direct link to depression or anxiety as primary side effects.
• However, some patients have shared experiences of feeling more anxious, fatigued, or emotionally low after starting the medication — though these effects are rare and may not be directly caused by the drug itself.
• Weight loss and appetite changes, which are part of how Mounjaro works, can also affect energy levels, sleep patterns, and mood, especially in people with a history of mood disorders.

Important Considerations:

• If you have a history of depression, anxiety, or other mental health conditions, talk to your doctor before starting Mounjaro.
• If you’re already on the medication and begin to experience mood swings, irritability, panic attacks, or sadness, seek medical advice immediately.
• Sometimes, changes in mental health can be influenced by multiple factors, including blood sugar levels, lifestyle shifts, or other medications — not just Mounjaro alone.

Bottom Line:
While Mounjaro doesn’t typically cause depression or anxiety, some individuals may experience emotional changes. It’s important to monitor your mental health and report any concerning symptoms to your healthcare provider right away.

When to Contact a Doctor

• You feel persistently anxious, sad, or emotionally numb
• You experience panic attacks or sudden mood swings
• Your sleep, appetite, or motivation significantly changes

Depression and anxiety are not common side effects of Mounjaro (tirzepatide), but some users report mood changes. Clinical trials have not shown a direct link, though individual reactions vary. If you experience emotional changes while taking Mounjaro, speak with your doctor